Clarksville, MO

Clarksville is a quiet river town in Pike County, Missouri, set right along the Mississippi River on scenic Route 79. Located about nine miles southeast of Louisiana, the community sits between the high bluffs at Lookout Point and the open water below Lock and Dam 24. Daily life here centers around the Great River Road corridor, which connects a charming historic downtown, the Apple Shed arts venue, and Riverfront Park.

ATTRGary Stevens / Public domain

Founded in 1819 and named for William Clark, the town has preserved much of its nineteenth-century character through a designated historic district full of classic brick storefronts and older homes. During the winter, the open water below the dam attracts hundreds of migrating bald eagles, making the annual Eagle Days celebration one of the community's favorite traditions. With its sweeping water views, local artisan shops, and relaxed pace, Clarksville offers a peaceful, tight-knit setting for anyone seeking small-town living on the river.