Greenville, MO

View of Greenville, MO
Image credit: Kbh3rd / CC BY 4.0
Population
440
U.S. Census Population Estimates Program · 2025
Elevation
407 ft
Median Home Value
$97,700
U.S. Census American Community Survey 5-Year · 2024
Median Rent
$484/mo
U.S. Census American Community Survey 5-Year · 2024
Median Income
$41,400
U.S. Census American Community Survey 5-Year · 2024

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Greenville in context.

About Greenville

Greenville is a city in and the county seat of Wayne County, Missouri, United States, that is located on U.S. Route 67 near the intersection with Route D and E along the St. Francis River. The 2020 census counted 443 residents. Greenville was incorporated and founded as the county seat of Wayne County in 1819. Greenville was named after Fort Greene Ville, Ohio, the site where General Anthony Wayne signed a treaty with the Native Americans after defeating them in the Battle of Fallen Timbers on August 20, 1794. There are two elementary schools—Greenville Elementary School and Williamsville Elementary School located in the nearby town of Williamsville for pre-kindergarten through sixth-grade students.

The short version is that Greenville carries an earlier story into the places people know and use now. That is the local read on Greenville: its past remains attached to the places people use now. This was the final battle of the Northwest Indian War. Greenville is located on the southern edge of the Ozark Mountains, situated in a hilly, forested landscape. U.S. Route 67 passes through Greenville.

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