Mayersville, MS

Mayersville is a town on the east bank of the Mississippi River, and the county seat for Issaquena County, Mississippi, United States. The 2020 census counted 433 residents. Mayersville is located in the Mississippi Delta region, known for cotton cultivation in the antebellum era. Once the trading center for the county, the town was superseded when railroads were built into the area. The short version is that Mayersville carries an earlier story into the places people know and use now. That is the local read on Mayersville: its past remains attached to the places people use now.

A 1950 survey by Philip Phillips of the Peabody Museum of Archaeology and Ethnology reported eleven ancient mounds. The first record of non-Native settlement was in 1830, when European-American Ambrose Gipson purchased a large body of land along the Mississippi River and founded "Gipson's Landing". Mayersville is in northern Issaquena County, just east of the Mississippi River, from which it is separated by a levee.