Seneca, MO

View of Seneca, MO
Image credit: TheWhitePelican / CC BY-SA 3.0
Population
2,343
U.S. Census Population Estimates Program · 2025
Elevation
850 ft
Median Home Value
$132,600
U.S. Census American Community Survey 5-Year · 2024
Median Rent
$902/mo
U.S. Census American Community Survey 5-Year · 2024
Median Income
$46,023
U.S. Census American Community Survey 5-Year · 2024

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Seneca in context.

About Seneca

Seneca is a Newton County city on the Missouri-Oklahoma line, platted in 1869 and named for the Seneca Nation. The post office opened that same year, and the city grew with one foot pointed toward the state line. Lost Creek runs close to town, with Missouri 43 through the city and U.S. 60 just south. Seneca's story also includes a difficult modern chapter: the 2008 tornado outbreak damaged homes north of town, and a memorial was later placed beside Lant's Feed and Country Store. The local shorthand is border town, Lost Creek, and a name carrying an older history westward.

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