Tuscumbia, MO

Tuscumbia is a village in and the county seat of Miller County, Missouri, United States, that is on the Osage River. The 2020 census counted 188 residents. Tuscumbia was laid out in 1837. The community's name most likely is a transfer from Tuscumbia, Alabama. The short version is that Tuscumbia carries an earlier story into the places people know and use now. That is the local read on Tuscumbia: its past remains attached to the places people use now. Tuscumbia is located in central Miller County on the north bank of the Osage River, near the junction of Missouri routes 17 and 52. Route 17 leads northeast 10 miles to Eugene and southeast 15 miles to Iberia, while Route 52 leads northwest 12 miles to Eldon and east 14 miles to St. Elizabeth.